Key result
Preoperative administration of pregabalin significantly delayed the time of first analgesic requirement and reduced total pethidine consumption compared to no pregabalin (p<0.001).
Why the study?
Postoperative pain management can be challenging once peripheral hypersensitivity and central nervous system hyperexcitability occur, prompting the evaluation of pre-emptive oral pregabalin before abdominal surgery to reduce pain intensity and analgesic requirements.
Does oral pregabalin reduce postoperative pain intensity and analgesic requirements in adult patients undergoing elective abdominal surgery?
RCT (n=60)
equally randomized
Does oral pregabalin reduce postoperative pain intensity and analgesic requirements in adult patients undergoing elective abdominal surgery?
p-value: p=<0.001
Preoperative administration of pregabalin significantly reduces postoperative pain and analgesic requirements following elective abdominal surgery, though it increases the incidence of dizziness.
Supports preoperative pregabalin to cut postoperative opioid needs after abdominal surgery; confirms efficacy in this RCT.
Background: Acute postoperative pain and side effects can be serious problems, due to either insufficient or excessive treatment. If analgesic treatment is begun after a painful stimulus, treating postoperative pain can be challenging because of the possibility of peripheral hypersensitivity and central nervous system hyperexcitability. Pre-emptive analgesia focuses on reducing postoperative opioid consumption and pain levels, decreasing the incidence of adverse events and improving patient satisfaction. Several pre-emptive analgesic regimens have been tried in the perioperative period, including opioids, nonsteroidal anti-inflammatory drugs, and so on. Aim of Study: To evaluate the effects of oral pregabalin, before abdominal surgery, on postoperative pain intensity and analgesic requirements (primary outcome), and the incidence of post-operative nausea and vomiting (secondary outcome). Patients and Methods: This randomized controlled trial was conducted on 60 adult healthy patients aged 21-50 years of both sex, ASA physical status I and II undergoing elective abdominal surgery (open or laparoscopic). Patients were equally randomized to: Group A: Received pregabalin 300mg/12hrs 24 hrs before surgery. Group B: Did not receive pregabalin. Results: Time of first analgesic requirement was signifi-cantly delayed in group A compared to group B (p-value <0.001). Total pethidine consumption was significantly lower in group A compared to group B (p-value <0.001). Incidence of PONV was 5 (16.67%) patients in group A and 13 (43.33%) in group B. Incidence of dizziness was 20 (66.67%) patients in group A and 4 (13.33%) in group B. Incidence of PONV was significantly lower in group A compared to group B (p -value=0.024). Incidence of dizziness was significantly higher in group A compared to group B (p-value <0.001). Respiratory depression and hypotension were insignificantly different between both groups. Conclusion: Preoperative administration of 300mg/12hrs 24hrs of pregabalin resulted in a significant reduction pain score, intraoperative fentanyl consumption, total pethidine consumption and incidence of PONV following elective abdominal surgery but with higher incidence of dizziness.
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Mohamed Koraitim (2023) conducted an RCT in elective abdominal surgery (n=60). pregabalin vs. no pregabalin was evaluated on postoperative pain intensity and analgesic requirements (p=<0.001). Preoperative administration of pregabalin significantly delayed the time of first analgesic requirement and reduced total pethidine consumption compared to no pregabalin (p<0.001).
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