Key result
Preoperative administration of NSAIDs (95% CI -0.61 to -0.14), COX-2 inhibitors, and gabapentin significantly reduced postoperative analgesic consumption at 24 hours compared to placebo.
Why the study?
Does preoperative preemptive drug administration reduce postoperative analgesic consumption in adults undergoing surgical procedures?
Population
3,172 adults undergoing surgical procedures from 39 randomized placebo-controlled trials
Comparison
Preoperative administration of pharmacological… vs Placebo
Design
Meta-analysis, randomized, placebo-controlled
Follow-up
24 h post surgery
Authors
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Preemptive COX-2 inhibitors and gabapentin reduce postoperative analgesic consumption; confirms efficacy for acute pain management in surgical adults.
Meta-Analysis (n=3,172)
Does preoperative preemptive drug administration reduce postoperative analgesic consumption in adults undergoing surgical procedures?
Preoperative administration of COX-2 inhibitors and gabapentin, but not opioids, effectively reduces acute postoperative pain and analgesic consumption.
Nir et al. (2016) conducted a meta-analysis in Acute postoperative pain (n=3,172). Preoperative pharmacological substances (NSAIDs, COX-2 inhibitors, gabapentin) vs. Placebo was evaluated on Reduction in postoperative analgesic consumption during 24 h post surgery (95% CI -0.61 to -0.14). Preoperative administration of NSAIDs (95% CI -0.61 to -0.14), COX-2 inhibitors, and gabapentin significantly reduced postoperative analgesic consumption at 24 hours compared to placebo.
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