What question did this study set out to answer?

To develop a magnetic resonance approach that isolates and directly measures intracellular water signals by shifting the extracellular signal.

June 20, 2005Magnetic Resonance in MedicineOpen Access

Uncovering of intracellular water in cultured cells

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Authors

JGJean‐Philippe GalonsUniversity of Arizona SLSilvia Lope‐PiedrafitaUniversitat Autònoma de Barcelona JDJoseph L. DivijakUniversity of Arizona

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Implication

In vitro study demonstrates separation of intracellular water signals in cultured cells, indicating a direct approach to measure cellular diffusion and relaxation.

Key Points

To develop a magnetic resonance approach that isolates and directly measures intracellular water signals by shifting the extracellular signal.
Cultured cells were maintained and evaluated within a hollow fiber bioreactor system.
A gadolinium contrast agent was added to the perfusion medium to induce a magnetic susceptibility shift in extracellular water at 9.4 T.
Extracellular water resonance frequency shifted by +185 Hz at 9.4 T, resolving it from the intracellular water signal.
The spectral separation permitted direct measurement of motional and relaxation properties specific to the intracellular compartment.

Cite This Study

Galons et al. (2005) studied this question.

synapsesocial.com/papers/6a9ff5693a35f4a2c890e6fd https://doi.org/10.1002/mrm.20565

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Implication

In vitro study demonstrates separation of intracellular water signals in cultured cells, indicating a direct approach to measure cellular diffusion and relaxation.

Uncovering of intracellular water in cultured cells

Discussion

Member takes

Implication

Key Points

Cite This Study

Uncovering of intracellular water in cultured cells

Discussion

Member takes

Implication

Key Points

Cite This Study

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