What question did this study set out to answer?

To evaluate the relationship between menstrual characteristics, specifically age at menarche and menopause, and subsequent risk of developing breast cancer.

October 15, 1988CancerOpen Access

Menstrual factors and breast cancer risk

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To evaluate the relationship between menstrual characteristics, specifically age at menarche and menopause, and subsequent risk of developing breast cancer.
Prospective cohort study of 63,090 Norwegian women followed from 1961 through 1980, identifying 1,565 incident breast cancer cases.
Conducted multivariate analyses adjusted for age, urban or rural place of residence, parity, and age at first and last birth.
Breast cancer risk decreased with older age at menarche (P = 0.06; 4.0% increase per year decrease in age) and increased with older age at menopause (P = 0.005; 3.6% increase per year increase in age).
The protective effect of early menopause was strongest for breast cancer diagnosed at age 80 or older, while menstrual irregularities showed no clear association with risk.

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Implication

Prospective study finds earlier menarche and later menopause increase breast cancer risk in Norwegian women, indicating that lifetime estrogen exposure influences oncogenesis.

Cite This Study

Kvåle et al. (1988) studied this question.

synapsesocial.com/papers/6a9ff5b14f36274919babaec https://doi.org/10.1002/1097-0142(19881015)62:8<1625::aid-cncr2820620828>3.0.co;2-k

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Implication

Prospective study finds earlier menarche and later menopause increase breast cancer risk in Norwegian women, indicating that lifetime estrogen exposure influences oncogenesis.

Menstrual factors and breast cancer risk

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Discussion

Implication

Cite This Study

Menstrual factors and breast cancer risk

Key Points

Discussion

Implication

Cite This Study

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