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The purpose of this study was to investigate the influence of seed crystal size on the rate of nucleation in batch stirred‐tank crystallizers. Experimental results confirm the existence of such an effect. Nucleation rate data are correlated with a second‐order polynomial in seed crystal size; coefficients of the correlation are functions of the solute‐solvent system, crystallizer geometry, and mixing conditions. The empirical correlation is incorporated into a population balance model for determining the nucleation rate in multi‐seed crystallizers. The observed results are explained in terms of variations in impact energy, circulation frequency, and target efficiency.
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Bauer et al. (1974) studied this question.
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