Understanding the Mechanism and Prevention of Arterial Occlusive Thrombus Formation by Anti-Platelet Agents
Key result
Drugs that block events upstream of the final common pathway for platelet aggregation may be more effective antiplatelet agents than those that merely inhibit platelet aggregation.
Design
Review
Authors
Discussion
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Member takes
Implication
May support upstream platelet targeting in practice; leaves open confirmation of superiority in randomized trials.
PICO
P
Population
Arterial occlusive thrombus formation
I
Intervention / Comparator
Antiplatelet agents
Targeting upstream events in platelet activation and procoagulant activity may offer better prevention of atherothrombosis than merely inhibiting platelet aggregation via GP IIb/IIIa.
Cite This Study
Shinya Goto (2004) conducted a review in Arterial occlusive thrombus formation. Antiplatelet agents was evaluated. Drugs that block events upstream of the final common pathway for platelet aggregation may be more effective antiplatelet agents than those that merely inhibit platelet aggregation.