Genetic recombination and diversity of sapovirus in pediatric patients with acute gastroenteritis in Thailand, 2010–2018
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Key result
Sapovirus was detected in 1.6% of children hospitalized with acute gastroenteritis in Chiang Mai, Thailand, with GI.1 as the predominant genotype and the first identification of GII.1/GII.4 recombinant strains in the country.
Why the study?
Genetic recombination of human sapovirus has been reported globally, but no recombinant strains had yet been reported from Thailand.
Population
3,057 stool samples from hospitalized children with diarrhea in Chiang Mai, Thailand
Design
Observational surveillance study
Authors
Discussion
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Implication
First SaV recombinants reported in Thai children; extends regional surveillance data but leaves open clinical relevance pending larger studies.
Study Design
Type
Observational (n=3,057)
Multicenter
Yes
Structured PICO
P
Population
3,057 children aged neonate to 15 years hospitalized with acute gastroenteritis in Chiang Mai, Thailand, evaluated for sapovirus prevalence and genetic diversity between 2010 and 2018.
O
Outcome
Prevalence, genetic recombination, and genotype diversity of sapovirus (SaV)
The study demonstrates the genetic diversity of sapovirus in pediatric acute gastroenteritis in Thailand and reports the first identification of intragenogroup SaV recombinant strains in the country.
Limitations
- Use of single round PCR as a screening method may have resulted in a lower detection rate compared to real-time PCR
- Study was limited to hospitalized children in a single province
Cite This Study
Kumthip et al. (2020) conducted an observational in Acute gastroenteritis (n=3,057). Sapovirus was evaluated on Sapovirus detection rate. Sapovirus was detected in 1.6% of children hospitalized with acute gastroenteritis in Chiang Mai, Thailand, with GI.1 as the predominant genotype and the first identification of GII.1/GII.4 recombinant strains in the country.
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