Key result
A 6-month walking intervention led to a greater decrease in vascular cellular adhesion molecule, beta-2 microglobulin, total cholesterol, and triglycerides compared to control (P<0.20).
Why the study?
Does a walking intervention reduce inflammation in patients with diabetes mellitus and peripheral arterial/artery disease?
RCT (n=55)
Does a walking intervention reduce inflammation in patients with diabetes mellitus and peripheral arterial/artery disease?
p-value: p=<0.20
A 6-month walking intervention may reduce inflammatory and lipid biomarkers in patients with diabetes and peripheral arterial disease.
May support walking programs to lower biomarkers in diabetes with PAD; extends RCT evidence on exercise.
OBJECTIVES: In this pilot study, we sought to determine whether walking reduces inflammation in patients with diabetes mellitus and peripheral arterial/artery disease. METHODS: We obtained blood samples from patients with diabetes mellitus and peripheral arterial/artery disease. Intervention participants were advised to walk for 50 min 3 days per week for 6 months. Participants completed assessments of comorbidities and walking ability. Difference-in-difference analyses were used to assess the relationship between group assignment and each biomarker over time. RESULTS: We randomized 55 participants (control = 25 and intervention = 30). At 6 months and based on p values of <0.20, vascular cellular adhesion molecule, beta-2 microglobulin, total cholesterol, and triglycerides demonstrated a greater decrease among participants randomized to the intervention compared to the control. CONCLUSIONS: Walking may reduce inflammation in persons with diabetes mellitus and peripheral arterial/artery disease. Further research is needed to determine the impact of walking on inflammation in persons with vascular disease.
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Collins et al. (2013) conducted an RCT in Diabetes mellitus and peripheral arterial/artery disease (n=55). Walking intervention vs. Control was evaluated on Change in inflammation biomarkers (vascular cellular adhesion molecule, beta-2 microglobulin, total cholesterol, and triglycerides) (p=<0.20). A 6-month walking intervention led to a greater decrease in vascular cellular adhesion molecule, beta-2 microglobulin, total cholesterol, and triglycerides compared to control (P<0.20).
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