Key result
A 6-month lifestyle modification program consisting of diet and aerobic exercise significantly reduced systemic inflammation, including TNF-α levels (12.75 vs 15.14 pg/mL, p<0.05), and oxidative stress biomarkers compared to no intervention in obese patients with NASH.
Why the study?
Does lifestyle modification (aerobic exercise and diet control) improve inflammatory cytokines and oxidative stress markers in obese patients with non-alcoholic steatohepatitis?
RCT (n=80)
Randomized
No
Does lifestyle modification (aerobic exercise and diet control) improve inflammatory cytokines and oxidative stress markers in obese patients with non-alcoholic steatohepatitis?
Absolute Event Rate: 12.75% vs 15.14%
p-value: p=<0.05
A 6-month lifestyle modification program consisting of aerobic exercise and diet control significantly improves inflammatory cytokines and oxidative stress markers in obese patients with non-alcoholic steatohepatitis.
Supports lifestyle programs in obese NASH to lower inflammation; confirms RCT benefits on TNF-α and oxidative stress markers.
Background: Oxidative status may be an influential factor for increasing the progress and decreasing the effectiveness of nonalcoholic steatohepatitis treatment.Objective: This study aimed to examine effects of weight reducing program on inflammatory cytokines and oxidative stress markers among obese Saudi patients with non-alcoholic steatohepatitis.Material and Methods: Eighty obese patients with non-alcoholic steatohepatitis participated in this study, mean age was 44.27±3.46year and body mass index was 32.68±2.95kg/m 2 .All Subjects were included in two groups: The first group received life style modification in the form of treadmill aerobic exercises in addition to diet control where, the second group received no therapeutic intervention.Parameters of body mass index (BMI), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), conjugated dienes (CD), malondialdehyde (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD) and glutathione (GSH) were measured before and after 6 months at the end of the study. Results:The mean values of BMI, TNF-α, IL-6, CD and MDA were significantly decreased, while the mean values of GPx, SOD and GSH were significantly increased in patients of group (A) as a result of weight loss, while changes were not significant in group (B).Also, there were significant differences between mean levels of the investigated parameters in group (A) and group (B) at the end of the study. Conclusion:Within the limit of this study, life style modification modulates inflammatory cytokines and oxidative stress markers among obese Saudi patients with non-alcoholic steatohepatitis.
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Essam H. Jiffri (2018) conducted an RCT in Non-alcoholic steatohepatitis (NASH) and obesity (n=80). Lifestyle modification (aerobic exercise and diet control) vs. No therapeutic intervention was evaluated on Tumor necrosis factor-alpha (TNF-α) level at 6 months (pg/mL) (p=<0.05). A 6-month lifestyle modification program consisting of diet and aerobic exercise significantly reduced systemic inflammation, including TNF-α levels (12.75 vs 15.14 pg/mL, p<0.05), and oxidative stress biomarkers compared to no intervention in obese patients with NASH.
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