Key result
Metabolically healthy obese individuals had significantly higher levels of highly sensitive C-reactive protein (6.44 vs 2.98 mg/dl) and oxidative stress markers compared to normal weight controls.
Why the study?
Are inflammatory and oxidative stress markers elevated in metabolically healthy obese individuals compared to controls?
Population
100 healthy participants, including metabolically healthy obese individuals and controls
Design
Cross-sectional
Authors
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Hypothesis-generating for cardiometabolic risk in metabolically healthy obesity; leaves open causal links and clinical utility.
Case-Control (n=100)
No
Are inflammatory and oxidative stress markers elevated in metabolically healthy obese individuals compared to controls?
Absolute Event Rate: 6.44% vs 2.98%
p-value: p=<0.001
Metabolically healthy obese individuals exhibit elevated markers of low-grade chronic inflammation and oxidative stress, which may predispose them to future cardiovascular and metabolic diseases.
Hazhmat Ali (2023) conducted a case-control in Metabolically healthy obesity (n=100). Obesity (BMI > 30 kg/m²) vs. Normal weight (BMI < 25 kg/m²) was evaluated on Highly sensitive C-reactive protein (hs-CRP) level (mg/dl) (p=<0.001). Metabolically healthy obese individuals had significantly higher levels of highly sensitive C-reactive protein (6.44 vs 2.98 mg/dl) and oxidative stress markers compared to normal weight controls.
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