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May 20, 2021AntioxidantsOpen Access

Overweight and obesity are linked to increased pro-oxidant and proinflammatory status in plasma and PBMCs.

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Why the study?

Obesity is a major global public health concern characterized by higher cardiovascular risk and a pro-inflammatory profile, prompting assessment of oxidative stress in PBMCs and plasma inflammatory biomarkers across weight categories.

Comparison

Adults with normal weight vs overweight vs obesity

Key result

Overweight and obesity were associated with an increase in pro-oxidant and proinflammatory status in plasma and PBMCs compared to normal-weight adults.

Authors

MMMargalida Monserrat-MesquidaMQMaria Magdalena Quetglas‐LlabrésCBCristina Bouzas

Discussion

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Overview

May support biomarker monitoring in obesity; leaves open whether changes predict progression or reversal in prospective studies.

Study Design

Type

Cross-Sectional (n=150)

Structured PICO

P
Population
150 adults aged 55-80 years (60% women) from Spain, classified by BMI to assess oxidative stress and inflammatory biomarkers.
O
Outcome
Oxidative stress in peripheral blood mononuclear cells (PBMCs) and inflammatory biomarkers in plasma (including ROS, MDA, TNFα, and IL-6)surrogate

Overweight and obesity are associated with increased pro-oxidant and proinflammatory status in plasma and PBMCs, suggesting these biomarkers could monitor obesity progression or reversal.

Cite This Study

Monserrat-Mesquida et al. (2021) conducted a cross-sectional in Overweight and obesity (n=150). Overweight and obesity vs. Normal weight was evaluated on Oxidative stress in peripheral blood mononuclear cells (PBMCs) and inflammatory biomarkers in plasma. Overweight and obesity were associated with an increase in pro-oxidant and proinflammatory status in plasma and PBMCs compared to normal-weight adults.

synapsesocial.com/papers/6aa3cfe834a74eb94ec7fb12https://doi.org/10.3390/antiox10050813
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Characterization of the oxidative stress and inflammatory markers in metabolically healthy obese individuals2023
  2. 2Role of Peripheral Blood Mononuclear Cells in the Predisposition of Obese Individuals to Inflammation and Infection2013 · 37 citations
  3. 3Exploring the Relationship Between Inflammatory Biomarkers and Anthropometric Measures of Obesity in Healthy Adults: A Case Control Study2025 · 8 citations
  4. 4Biomarkers of Metabolism and Inflammation in Individuals with Obesity and Normal Weight: A Comparative Analysis Exploring Sex Differences2025
  5. 5Circulating Oxidized LDL and Inflammation in Extreme Pediatric Obesity2011 · 99 citations