Key result
Obesity-related inflammation is linked to worse mental health, specifically lower self-esteem and increased depression symptoms.
Why the study?
Elucidating the overlapping biochemical mechanisms involving inflammation and oxidative stress is needed to better understand and address obesity and related metabolic disorders.
Population
122 metabolically unhealthy people with obesity in a Greek cohort
Design
Observational study
Authors
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Associations between inflammatory/oxidative stress markers and mental health in obesity are hypothesis-generating; prospective studies required before clinical adoption.
Observational (n=122)
Effect estimate: Beta=-0.019
p-value: p=0.019
Obesity-related systemic inflammation is associated with worse self-esteem and depression symptoms, suggesting overlapping mechanisms in metabolic and mental health.
Amerikanou et al. (2023) conducted an observational in Metabolically unhealthy obesity (n=122). Peripheral inflammation (IL-6, TNF-a) vs. Lower levels of inflammation was evaluated on Association between interleukin-6 (IL-6) and Rosenberg Self-Esteem Scale (RSES) (Beta=-0.019, p=0.019). Obesity-related systemic inflammation was associated with worse mental health, specifically a negative association between IL-6 and self-esteem (Beta=-0.019) and a positive association between TNF-a and depression symptoms (Beta=0.003).
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