Key result
Radiofrequency ablation guided by a three-dimensional mapping system successfully established left bundle branch block in 80% (8 of 10) of canines.
Why the study?
Few studies have established animal models of left bundle branch block using three-dimensional mapping systems.
A three-dimensional mapping system provides a reliable and effective guide for left bundle branch ablation to create a canine heart failure model.
Establishes feasibility of 3D-guided LBBB ablation in canines; leaves open translation to clinical HF models.
Objective: Few studies have been conducted to establish animal models of left bundle branch block by using three-dimensional mapping systems. This research was aimed at creating a canine left bundle branch block model by using a three-dimensional mapping system. Materials and Methods: We used a three-dimensional mapping system to map and ablate the left bundle branch in beagles. Results: Ten canines underwent radiofrequency ablation, among which left bundle branch block was successfully established in eight, one experienced ventricular fibrillation, and one developed third-degree atrioventricular block. The maximum HV interval measured within the left ventricle was 29.00 ± 2.93 ms, and the LBP-V interval at the ablation site was 20.63 ± 2.77 ms. The LBP-V interval at the ablation target was 71.08% of the maximum HV interval. Conclusion: This three-dimensional mapping system is a reliable and effective guide for ablation of the left bundle branch in dogs.
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He et al. (2023) studied Left bundle branch block (n=10). Radiofrequency ablation guided by a three-dimensional mapping system was evaluated on Successful establishment of left bundle branch block. Radiofrequency ablation guided by a three-dimensional mapping system successfully established left bundle branch block in 80% (8 of 10) of canines.
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