What question did this study set out to answer?

To assess the effects of daily preventive zinc supplementation on cytokine production, T-cell populations, and leukocyte counts in young children from communities with high rates of zinc deficiency.

February 6, 2020Journal of NutritionOpen Access

Daily Preventive Zinc Supplementation Decreases Lymphocyte and Eosinophil Concentrations in Rural Laotian Children from Communities with a High Prevalence of Zinc Deficiency: Results of a Randomized Controlled Trial

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Authors

CKChidchamai KewcharoenwongChiang Mai University GSGertrud U. SchusterWestern Human Nutrition Research Center KWK. Ryan WessellsUniversity of California, Davis

Discussion

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Implication

Randomized trial reveals daily preventive zinc supplementation reduces lymphocyte and eosinophil concentrations in young children, suggesting these immune markers indicate zinc response.

Key Points

To assess the effects of daily preventive zinc supplementation on cytokine production, T-cell populations, and leukocyte counts in young children from communities with high rates of zinc deficiency.
Randomized trial of 512 children aged 6–23 months in rural Laos assigned to daily preventive zinc tablets (7 mg Zn/d), daily multiple micronutrient powder, therapeutic zinc for diarrhea (20 mg Zn/d for 10 days), or daily placebo powder for 9 months (NCT02428647).
Cytokine production from whole blood cultures, T-cell concentrations, and complete blood counts with differential leukocyte counts were assessed at baseline and endline using ANCOVA adjusted for baseline covariates and zinc status.
Endline lymphocyte concentrations were significantly lower in the preventive zinc group compared with the placebo group (mean ± SE: 5018 ± 158 vs 5640 ± 160 cells/μL, P = 0.032).
Among children with baseline plasma zinc below the median, eosinophil concentrations were significantly lower in the preventive zinc group than the placebo group (524 ± 44 vs 600 ± 41 cells/μL, P = 0.012; interaction P = 0.0036).
Intervention groups showed no significant differences in T-cell cytokines (IL-2, IFN-γ, IL-13, IL-17), LPS-stimulated cytokines (IL-1β, IL-6, TNF-α, IL-10), or overall T-cell concentrations.

Cite This Study

Kewcharoenwong et al. (2020) studied this question.

synapsesocial.com/papers/6a9ffc84b5fefa4cb5b56fe3 https://doi.org/10.1093/jn/nxaa037

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Implication

Randomized trial reveals daily preventive zinc supplementation reduces lymphocyte and eosinophil concentrations in young children, suggesting these immune markers indicate zinc response.

Daily Preventive Zinc Supplementation Decreases Lymphocyte and Eosinophil Concentrations in Rural Laotian Children from Communities with a High Prevalence of Zinc Deficiency: Results of a Randomized Controlled Trial

Discussion

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Implication

Key Points

Cite This Study

Daily Preventive Zinc Supplementation Decreases Lymphocyte and Eosinophil Concentrations in Rural Laotian Children from Communities with a High Prevalence of Zinc Deficiency: Results of a Randomized Controlled Trial

Discussion

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Implication

Key Points

Cite This Study

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