DNA microarray expression profiling of a new t(8;13) AML case allows identification of possible leukemogenic transformation markers

previously not described abnormality, a chromosomal translocation between chromosomes 8 and 13 t(8;13) identified by conventional cytogenetics, and several altered genes detected by DNA microarray assay, suggesting that the t(8;13) rearranged region results in altered gene expression patterns. Case reportThe patient was a 72-year-old female admitted to the Instituto Nacional de Cancer (INCA), Rio de Janeiro, Brazil.She presented with a history of increasing fatigue and dyspnea.Past medical history included arterial hypertension, coronary artery disease, myalgia and pneumonia.The laboratory results at diagnosis revealed: white blood cell count 36.9 × 10 9 /L with 41% monocytoid blasts, hematocrit 23%, hemoglobin 7.6 g/dL, platelets 131.0 × 10 9 /L and lactate dehydrogenase 806 IU/L.