Key result
Larger atrial septal defect size and increased right-sided tricuspid E/e' ratio correlated with severe pulmonary hypertension in adults with ostium secundum ASD (AUC 0.704, P<0.001 for ASD size).
Observational (n=92)
Effect estimate: AUC 0.704 (95% CI 0.59-0.818)
p-value: p=<.001
In adults with ostium secundum ASD, larger defect size and increased right-sided tricuspid E/e' ratio correlate with severe pulmonary hypertension, which is associated with both right and left ventricular dysfunction.
OBJECTIVE: To identify echocardiographic factors that correlate with pulmonary hypertension (PH) in adults with ostium secundum atrial septal defect (ASD). METHODS: Between November 2009 and November 2013, 92 adults with ASD were studied. All had clinical history and transthoracic echocardiogram. RESULTS: Thirty-nine percent of patients had severe PH defined as systolic pulmonary artery pressure (sPAP) of 70 mm Hg or more. The size of ASD (31.84±8.21 mm) and a right-sided tricuspid inflow E-wave to tissue Doppler e'-wave ratio >6.2 correlated with severe PH with AUC of 0.704 (CI 95%=0.59 to 0.818, P<.001) and 0.65 (CI 95%=0.531 to 0.773, P<.014), respectively. Multivariate logistic regression showed that sPAP >70 mm Hg was the variable that most precisely correlated with right ventricular (RV) dysfunction as evidenced by TAPSE <17 mm and RV fractional shortening area (RVFSA) <35%. Left ventricular (LV) diastolic function was also significantly reduced in the group with severe PH with mitral inflow E/A ratio of 0.73±0.23 vs 1.13±0.42 in the group without severe PH (sPAP <70 mm Hg, (P=.001). The pulmonary (Qp) to systemic (Qs) cardiac output ratio (3.09±1.12) and right-sided tissue Doppler S <9.5 cm/s most accurately predicted a Tei index >0.55. CONCLUSIONS: Larger size of ASD using the QP/QS ratio and increased right-sided tricuspid E/e' ratio correlated with severe PH with a sPAP of 70 mm Hg or more. Patients with severe PH had more severe RV dysfunction as evaluated by TAPSE and RVFSA in comparison to those with PH <70 mm Hg. LV diastolic function was also reduced in the severe PH group.
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Cossío-Aranda et al. (2016) conducted an observational in Ostium secundum atrial septal defect (n=92). Echocardiographic factors (ASD size and tricuspid E/e' ratio) was evaluated on Severe pulmonary hypertension (systolic pulmonary artery pressure ≥70 mm Hg) (AUC 0.704, 95% CI 0.59-0.818, p=<.001). Larger atrial septal defect size and increased right-sided tricuspid E/e' ratio correlated with severe pulmonary hypertension in adults with ostium secundum ASD (AUC 0.704, P<0.001 for ASD size).
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