Key result
Sympathetic ganglia of rats and cats contain multiple forms of gangliosides, and rat ganglia incorporate 14C from glucose, pyruvate, and glucosamine in vitro.
This preclinical study demonstrates the presence and active in vitro metabolism of gangliosides in mammalian sympathetic ganglia.
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No immediate clinical implications; leaves open ganglioside roles in autonomic cardiovascular regulation.
Sympathetic ganglia of the rat and cat were examined for the occurrence and distribution of gangliosides. Each rat superior cervical ganglion contained 0.3 nmol of ganglioside‐sialic acid. Extracts of cat superior cervical and nodose ganglia were chromatographed on silica gel thin‐layer plates. The resulting patterns suggested that similar distributions of multiple forms of gangliosides occur in these two tissues, with the fast‐moving gangliosides predominating. The metabolic activity of gangliosides was also investigated in rat superior cervical ganglia in vitro. Evidence was obtained that 14C from [U‐14C]glucose, [U‐14C]pyruvate, and [U‐14C]glucosamine was incorporated into the gangliosides.
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Harris et al. (1972) studied this question. Sympathetic ganglia of rats and cats contain multiple forms of gangliosides, and rat ganglia incorporate 14C from glucose, pyruvate, and glucosamine in vitro.
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