Cytosolic gangliosides of rat brain: Their fractionation into protein‐bound complexes of different ganglioside compositions

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Population

Rat brain cytosolic extract (from rats injected with N-(3H)acetylmannosamine)

Comparison

Fractionation techniques vs Purified gangliosides

Design

Preclinical

Authors

Discussion

No immediate clinical implications from rat data; leaves open functional roles of these complexes in human neurons.

Population

Rat brain cytosolic extract (from rats injected with N-(3H)acetylmannosamine)

Intervention

Fractionation techniques (ammonium sulphate fractionation, Sepharose 6B gel filtration, and hydroxylapatite-cellulose chromatography)

Comparator

Purified gangliosides

Outcome

Identification and composition of ganglioside-protein complexes

Rat brain cytosolic gangliosides exist as specific protein-bound complexes (GM1, GD1a, GT1b), rather than free molecules.

Sonnino et al. (1984) studied this question.

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