Population
Rats (rat brain subcellular gangliosides)
Comparison
Pentylenetetrazol-induced convulsions following… vs Non-convulsed animals
Design
Preclinical
Follow-up
18 h
Authors
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Rat convulsion data should not inform clinical seizure management; leaves open ganglioside metabolism as a hypothesis-generating epilepsy target.
Pentylenetetrazol-induced convulsions decrease radioactive labeling in specific polysialogangliosides in rat brain subcellular fractions, possibly due to membrane-bound neuraminidase activation.
Yohe et al. (1980) studied this question.
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