Key result
Time to onset and time to peak of the RVOT systolic spectral signal correlated better with pulmonary hypertension severity than right ventricular fractional area change (P<0.0001).
Why the study?
Does the right ventricular outflow tract spectral Doppler signal correlate with right ventricular systolic performance and pulmonary hypertension severity?
Observational (n=80)
Does the right ventricular outflow tract spectral Doppler signal correlate with right ventricular systolic performance and pulmonary hypertension severity?
p-value: p=<0.0001
Timing of onset and peak of the RVOT systolic spectral signal are useful markers for characterizing pulmonary artery systolic pressure severity, while total duration of RVOT ejection reflects RV systolic performance.
May support RVOT timing parameters for PH severity grading on echo; extends correlative data but remains hypothesis-generating.
AIMS: Right ventricular outflow tract (RVOT) acceleration shortens with chronic pulmonary hypertension (cPH). However, the overall value of this spectral Doppler signal in the assessment of PH patients is not well understood. METHODS AND RESULTS: Markers of RV systolic performance, time to onset, time to peak, and total duration of the RVOT systolic spectral Doppler signal were examined. Group I consisted of 28 patients without PH [50 +/- 15 years and mean pulmonary artery systolic pressure (PASP) of 30 +/- 8 mmHg] and Group II included 52 patients with cPH (56 +/- 14 years and mean PASP of 80 +/- 27 mmHg; P < 0.0001). As expected, Group II patient's markers showed worse RV performance. In addition, Group II had a longer time to onset, a shorter time to peak, and a shorter total duration of the RVOT systolic signal than Group I. Both time to onset (r = 0.66 vs. r = -0.53; P < 0.0001) and time to peak (r = 0.65 vs. r = 0.50; P < 0.0001) of the RVOT signal correlated better with PH than RV fractional area change. Conversely, RV fractional area change correlated better with total duration of RVOT ejection (r = 0.66 vs. r = 0.58; P < 0.0001) than with PASP. CONCLUSION: Timing of onset and peak of the RVOT systolic spectral signal appears to be useful in characterizing the severity of the PASP, while the total duration of RVOT ejection is a better predictor of the systolic performance of the RV in PH patients. More studies are now required to determine the clinical utility of prospectively measuring RVOT in cPH.
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López‐Candales et al. (2010) conducted an observational in Chronic pulmonary hypertension (n=80). Chronic pulmonary hypertension vs. No pulmonary hypertension was evaluated on Correlation of time to onset and time to peak of the RVOT signal with pulmonary hypertension (p=<0.0001). Time to onset and time to peak of the RVOT systolic spectral signal correlated better with pulmonary hypertension severity than right ventricular fractional area change (P<0.0001).
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