Key result
Prolonged (1-4 hr) lower body negative pressure combined with fluid-loading is being developed as a countermeasure against postflight orthostatic intolerance.
Prolonged lower body negative pressure combined with fluid loading or pharmacologic agents is being developed as a countermeasure for postflight orthostatic intolerance in space programs.
Should not yet change space medicine practice; leaves open efficacy of prolonged lower body negative pressure with fluid loading.
Exposure to prolonged (1-4 hr) lower body negative pressure (LBNP) is a countermeasure against postflight orthostatic intolerance which is used in the Soviet space program and planned for use in the American space program. LBNP in combination with fluid-loading is believed to act by promoting a transient positive fluid balance resulting in an increase in vascular, as well as extravascular fluid. Inflight LBNP also may provide beneficial orthostatic effects by restoring baroreceptor reflex functions and/or lower body venous compliance. Current research efforts at the Johnson Space Center are directed towards increasing the effectiveness and efficiency of the LBNP and saline countermeasure. A promising avenue may involve combining pharmacologic agents, such as inhaled anti-diuretic hormone, or mineralocorticoids, with mechanical stimuli such as LBNP.
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S. M. Fortney (1991) conducted a review in postflight orthostatic intolerance. Lower body negative pressure (LBNP) was evaluated. Prolonged (1-4 hr) lower body negative pressure combined with fluid-loading is being developed as a countermeasure against postflight orthostatic intolerance.
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