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An improved, scalable synthetic route to the quinazolinone natural product 2,3-dihydropyrrolo[1,2- a ]quinazolin-5(1 H )-one is reported. The applicability of this method to analogue synthesis and the synthesis of related natural products is explored. Finally, reactivity of the scaffold to a variety of electrophilic reagents, generating products stereoselectively, is reported.
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Sutherell et al. (2016) studied this question.
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