Key result
Anticoagulant therapy in children requires specific dosing and monitoring due to pharmacokinetic differences, though current management still largely relies on extrapolating adult guidelines.
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Pediatric thromboembolism management currently relies on extrapolating adult guidelines, emphasizing the need for pediatric-specific clinical trials to determine optimal antithrombotic dosing and safety.
Thrombosis is the result of an imbalance between two complex systems: hemostasis and fibrinolysis.Although the incidence of thromboembolism is lower in children than in adults, the associated morbidity is clinically relevant.This paper summarizes the main risk factors, important to define effective strategies for primary thromboprophylaxis in children at risk, the diagnostic criteria and the optimal therapeutic approach, which, until now, have mostly been extrapolated from the adult's recommendations.
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Frăsinariu et al. (2017) conducted a review in Thromboembolic disease. Anticoagulant and thrombolytic therapy was evaluated. Anticoagulant therapy in children requires specific dosing and monitoring due to pharmacokinetic differences, though current management still largely relies on extrapolating adult guidelines.
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