Key result
A review of thrombosis in neonates, infants, and older children highlights that while many thrombotic risk factors have been identified, indications for therapeutic interventions remain poorly defined.
Provides a comprehensive overview of the causes, clinical presentation, and management of thrombosis in neonates, infants, and older children.
Therapy for pediatric thrombosis warrants individualized caution; leaves open the need for prospective trials to define intervention thresholds.
During the last decade much progress has been made toward better understanding of the underlying reasons causing thromboembolism in children. A considerable number of acquired and hereditary thrombotic risk factors have been identified which may also have an impact on therapeutic decisions and prognosis concerning outcome and the risk of a second event. However, indications for therapeutic interventions, such as thrombolysis and prophylactic anticoagulation with respect to the different clinical conditions and their combination with other risk factors, are not yet well defined. The following article describes the causes, clinical presentation and management of thrombosis in neonates, infants and older children, focusing on the clinically most relevant conditions.
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Schneppenheim et al. (2006) conducted a review in Thrombosis. A review of thrombosis in neonates, infants, and older children highlights that while many thrombotic risk factors have been identified, indications for therapeutic interventions remain poorly defined.
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