Key result
Review of preterm infant thrombotic disorders highlights heavy reliance on extrapolated adult treatment data.
This review highlights the risk factors and management of thrombosis in preterm infants, emphasizing the current reliance on adult data for anticoagulation protocols.
Reliance on adult-derived anticoagulation in preterm thrombosis demands caution; leaves open the need for dedicated infant trials.
In paediatrics, sick preterm infants are at highest risk of developing thrombotic complications. Haemostasis is in a fine balance in the neonatal period, despite age-related differences in coagulation proteins. However, both inherited and acquired risk factors can disrupt this balance and can lead to thrombosis. Important risk factors are sepsis, asphyxia, dehydration, central venous lines and inherited and acquired thrombophilia. Among various treatment modalities, anticoagulation is primarily used in the management of thrombosis. Different agents, dosages and durations of treatment in this age group are extrapolated from adult data. The article reviews the epidemiology, pathophysiology, risk factors, diagnosis and treatment of thrombotic disorders in preterm infants.
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Bhat et al. (2012) conducted a review in Thrombosis. This review summarizes the epidemiology, pathophysiology, risk factors, diagnosis, and treatment of thrombotic disorders in preterm infants, highlighting that treatments are often extrapolated from adult data.
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