Why the study?
The coagulation and thrombotic systems of infants differ fundamentally from older children and adults, and their unique physiology can contribute to a procoagulant state with high morbidity and mortality.
This review provides an overview of the epidemiology, diagnosis, and management of congenital and acquired thrombotic disorders in neonates.
Neonates require age-specific thrombosis evaluation; leaves open standardized prevention and treatment protocols.
The coagulation and thrombotic systems of an infant are fundamentally different from those of adults and older children. Hemostatic factors have inherently lower circulation levels in infants and are also affected prenatally by conditions of pregnancy. The unique physiology of neonates can contribute to a procoagulant state, which can result in a high level of morbidity and mortality. This review outlines the epidemiology, clinical characteristics, diagnosis and management, and etiologies of congenital and acquired forms of thrombotic disorders, with a discussion of the evaluation for hypercoagulation.
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Knopoff et al. (2024) studied this question.
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