Key result
LMWH serves as the primary prophylaxis for neonatal thrombosis driven by central catheters.
Why the study?
The pathogenesis and risk factors of neonatal thrombosis, including the role of central catheter installment and other maternal, fetal, and neonatal factors, require detailed analysis to inform prophylaxis.
This review highlights central catheter placement as the primary risk factor for neonatal thrombosis and outlines the principles of prophylaxis using low molecular weight heparins.
Reinforces neonatal thrombosis vigilance with central catheters; leaves open LMWH prophylaxis standardization pending higher-level evidence.
Data analysis on the pathogenesis and risk factors of neonatal thrombosis was carried out. The main risk factor of any neonatal thrombosis is central catheter installment, but other maternal, fetal and neonatal factors should be taken into consideration. We discuss the epidemiology of neonatal thrombosis and the main features of the hemostasis system in newborns, the most significant risk factors, including genetic and acquired thrombophilia. We consider the von Willebrand factor activity and ADAMTS-13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) level in the development of neonatal thrombotic microangiopathy. Finally, we discuss the basic principles of prevented neonatal thrombosis by using low molecular weight heparins.
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Vorobеv et al. (2021) conducted a review in Neonatal thrombosis. Central catheter installment and low molecular weight heparins was evaluated. Central catheter installment is the main risk factor for neonatal thrombosis, and low molecular weight heparins form the basic principles of prophylaxis.
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