Key result
High adherence to the MIND diet was associated with 58% lower odds of having a metabolically unhealthy phenotype compared to low adherence (OR 0.42; 95% CI 0.20-0.90).
Why the study?
Data were lacking regarding the relationship between the MIND diet and metabolic health.
Does adherence to the MIND diet reduce the odds of a metabolically unhealthy phenotype and affect serum BDNF concentrations in adults?
Cross-Sectional (n=527)
Yes
Does adherence to the MIND diet reduce the odds of a metabolically unhealthy phenotype and affect serum BDNF concentrations in adults?
Odds Ratio: 0.42 (95% CI 0.2–0.9)
Higher adherence to the MIND diet is associated with significantly lower odds of a metabolically unhealthy phenotype, particularly among women and normal-weight individuals, but is not associated with serum BDNF concentrations.
MIND diet adherence linked to metabolic health and BDNF in adults; leaves open causal effects and clinical relevance.
Background: There is a lack of data regarding the Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet and metabolic health. Objectives: This study assessed the relation between MIND diet and metabolic health status relative to serum brain-derived neurotrophic factor (BDNF) concentrations. Methods: This was a cross-sectional study of 527 adults (286 males and 241 females) recruited from 20 schools in 6 different educational districts of Isfahan, Iran. Dietary intakes of participants were collected by a validated 168-item food frequency questionnaire, and MIND diet score was estimated. Anthropometric indices, blood pressure, biochemical parameters, and BDNF concentrations were assessed for all participants. The metabolically unhealthy (MU) phenotype was determined based on blood pressure, glycemic and lipid profiles, chronic inflammation, and insulin resistance. Results: The frequency of MU phenotype among obese/overweight and normal-weight individuals was 79.5 % and 20.5 %, respectively. After adjustment for confounders, individuals in the top tertile of the MIND diet scores had 58 % lower odds of having the MU phenotype than individuals in the bottom tertile (odds ratios [ORs]: 0.42; 95 % confidence interval [CI]: 0.20, 0.90). In the fully adjusted model, females and normal-weight individuals had 81 % (OR: 0.19; 95 % CI: 0.04, 0.83) and 89 % (OR: 0.11; 95 % CI: 0.02, 0.69) lower chance of developing the MU phenotype, respectively. In addition, significant inverse associations between adherence to the MIND diet and high-blood pressure and hypertriglyceridemia were found. No significant association was found between adherence to MIND diet and odds of low BDNF concentrations. Conclusions: Adherence to MIND diet is inversely associated with odds of MU phenotype, especially among women and normal-weight individuals. BDNF concentration is not associated with MIND diet and MU status.
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Tirani et al. (2024) conducted a cross-sectional in Metabolically unhealthy phenotype (n=527). MIND diet vs. Bottom tertile of MIND diet scores was evaluated on Metabolically unhealthy (MU) phenotype (OR 0.42, 95% CI 0.20, 0.90). High adherence to the MIND diet was associated with 58% lower odds of having a metabolically unhealthy phenotype compared to low adherence (OR 0.42; 95% CI 0.20-0.90).
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