Drug delivery is one of the most important challenges in the domain of health. Non‐toxic and biocompatible carriers are provided by human serum albumin nano‐capsule (HSA/NC) for drug delivery applications. In this study, HSA, with high loadings of drug‐modified cobalt ferrite (CoFe 2 O 4 ) magnetic nanoparticle (CoFe 2 O 4 /MNPs) was fabricated for epirubicin anticancer drug delivery. In the initial step, CoFe 2 O 4 /MNPs was synthesised via co‐precipitation technique and characterised by X‐ray powder diffraction, vibrating sample magnetometry, energy dispersive X‐ray analysis, scanning electron microscopy and map analysis. Furthermore, CoFe 2 O 4 /MNPs and epirubicin were loaded into HSA/NC and utilised as a novel system against breast cancer cell line (MCF‐7). IC 50 for free epirubicin, unloaded CoFe 2 O 4 /MNPs/HSA/NC, CoFe 2 O 4 /MNPs and epirubicin‐loaded CoFe 2 O 4 /MNPs/HSA/NC were 7.7, 2400, 840 and 430 μg/ml, respectively. The results obtained revealed high cytotoxicity effect of epirubicin‐loaded CoFe 2 O 4 /MNPs on breast cancer cell line.
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Karimi et al. (2017) studied this question.
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