Protective Effect and Mechanism of Nanofiber Membrane Loaded With Curcumin Inclusion Compound in Periodontitis Oxidative Stress

Periodontitis, a leading cause of tooth loss, is conventionally treated by mechanical curettage and antibiotics, which may cause adverse effects. Curcumin (Cur), a natural anti‐inflammatory and antioxidant agent, shows therapeutic potential but suffers from low solubility and bioavailability. To overcome these limitations, we developed an electrospun nanofiber membrane (HP‐Cur‐IC/poly‐L‐lactone‐co‐ε‐caprolactone [PLCL]) containing cyclodextrin‐encapsulated Cur for localized sustained drug delivery within periodontal pockets. The resulting membrane exhibited improved water solubility, mechanical strength, and drug release profile. It demonstrated significant antioxidant and antibacterial effects, as evidenced by reductions in oxidative stress markers and bacterial viability. Furthermore, the membrane modulated the JAK2/STAT3 and ERK/JNK/p38 signaling pathways, alleviating oxidative damage in periodontal tissues. These findings suggest that the HP‐Cur‐IC/PLCL nanofiber membrane represents a promising nonsurgical strategy for periodontitis treatment.