Key result
Coexpression of complementary two-domain fragments of the DHPR pore subunit completely recovered intramembrane charge movement and voltage-evoked Ca2+ transients in dysgenic myotubes.
Coexpression of complementary two-domain fragments of the DHPR pore subunit can recover a functional voltage sensor capable of triggering excitation-contraction coupling in skeletal myotubes.
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Recovers EC coupling in dysgenic models; leaves open translation to therapies for muscle channelopathies.
Ahern et al. (2001) studied Muscular dysgenesis (in vitro model). Coexpression of I-II and III-IV domain fragments of the Ca2+ channel vs. Expression of single fragments (I-II or III-IV alone) or full-length α1S was evaluated on Recovery of DHPR intramembrane charge movement and voltage-evoked Ca2+ transients. Coexpression of complementary two-domain fragments of the DHPR pore subunit completely recovered intramembrane charge movement and voltage-evoked Ca2+ transients in dysgenic myotubes.
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