Key result
Increased coronary flow in isolated guinea pig hearts rapidly and significantly increased ATP release by at least tenfold compared to basal release, suggesting it induces coronary vasodilatation.
Effect estimate: at least tenfold increase
Increased coronary flow in isolated guinea pig hearts induces a tenfold increase in ATP release, which may mediate coronary vasodilatation.
May link flow to ATP-mediated vasodilatation in guinea pig hearts; leaves open translation to human coronary regulation.
The Langendorff heart preparation was used to investigate the release of ATP from the guinea pig heart in response to increased coronary flow. The lucifer-in-luciferase firefly technique was used to determine levels of ATP in the perfusate. During periods of increased flow, ATP release was rapidly and significantly increased by at least tenfold the basal release. The pressure/flow ratio was reduced in increased-flow conditions suggesting that coronary vasodilatation had occurred. It is concluded that ATP release from the guinea pig heart is increased under raised-flow conditions. It is suggested that this ATP release induces coronary vasodilatation.
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Vials et al. (2008) studied this question. Increased coronary flow vs. Basal flow was evaluated on ATP release in the perfusate (at least tenfold increase). Increased coronary flow in isolated guinea pig hearts rapidly and significantly increased ATP release by at least tenfold compared to basal release, suggesting it induces coronary vasodilatation.
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