February 1, 1978Circulation ResearchOpen Access

Adenosine, theophylline, and perfusate pH in the isolated, perfused guinea pig heart.

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Population

Isolated, perfused, spontaneously beating guinea pig hearts

Comparison

Alterations in perfusate pH via increased Pco2… vs Normal perfusate pH and absence of…

Design

Preclinical

Authors

GMGary F. MerrillRutgers, The State University of New Jersey FHF. J. HaddyUniversity of Oklahoma Medical Center JDJ. M. DabneyAmerican Dental Association

Discussion

Member takes

Implication

Hypothesis-generating in isolated hearts; leaves open whether pH-adenosine interaction regulates coronary flow in vivo.

Structured PICO

Population

Isolated, perfused, spontaneously beating guinea pig hearts

Intervention

Alterations in perfusate pH (7.20, 6.89, 7.69) via increased Pco2, combined with exogenous adenosine and theophylline

Comparator

Normal perfusate pH (7.42/7.43) and absence of adenosine/theophylline

Outcome

Coronary vasodilation (coronary flow)surrogate

Coronary vasodilation produced by adenosine is pH sensitive, suggesting hydrogen ions may participate in coronary flow regulation via interaction with adenosine.

Cite This Study

Merrill et al. (1978) studied this question.

synapsesocial.com/papers/6a868c7f2ccb7b2c5b17a882 https://doi.org/10.1161/01.res.42.2.225

View Full Paper

Ask AI

Bookmark

Adenosine, theophylline, and perfusate pH in the isolated, perfused guinea pig heart.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Adenosine, theophylline, and perfusate pH in the isolated, perfused guinea pig heart.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider