October 1, 1987Circulation ResearchOpen Access

Adenosine release by the isolated guinea pig heart in response to isoproterenol, acetylcholine, and acidosis: the minimal role of vascular endothelium.

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Population

Isolated perfused guinea pig hearts

Comparison

Infusion of isoproterenol, acetylcholine, or… vs Baseline/control values

Design

Preclinical

Authors

HBHubert J. BardenheuerHeidelberg University BWB. K. WheltonMichigan State University HSH. V. SparksHarvard University

Discussion

Member takes

Implication

Refines adenosine source models in isolated hearts; leaves open endothelial contributions in vivo and clinical translation.

Structured PICO

Population

Isolated perfused guinea pig hearts

Intervention

Infusion of isoproterenol, acetylcholine, or hydrochloric acid (acidosis) after selective labelling of endothelial adenine nucleotides with 3H-adenosine

Comparator

Baseline/control values

Outcome

Total adenosine release, radioactive adenosine release, and relative specific activity of venous effluent adenosinesurrogate

In isolated guinea pig hearts, adenosine released in response to isoproterenol and acetylcholine primarily originates from myocytes rather than the vascular endothelium.

Cite This Study

Bardenheuer et al. (1987) studied this question.

synapsesocial.com/papers/6a71d41d35aa2c282ce2f347 https://doi.org/10.1161/01.res.61.4.594

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Adenosine release by the isolated guinea pig heart in response to isoproterenol, acetylcholine, and acidosis: the minimal role of vascular endothelium.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Adenosine release by the isolated guinea pig heart in response to isoproterenol, acetylcholine, and acidosis: the minimal role of vascular endothelium.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider