Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 1, 1994Cardiovascular Research

Stimulation of endothelial adenosine A1 receptors enhances adhesion of neutrophils in the intact guinea pig coronary system

View Full Paper
Ask AI
Bookmark
Share

Population

Isolated perfused guinea pig hearts injected with 600,000 neutrophils prepared from guinea pig or human blood

Comparison

Adenosine infusion, A1 receptor agonist… vs Control

Design

Preclinical

Authors

SZStefan ZahlerHokkaido Pharmaceutical UniversityBBB.F. BeckerLudwig-Maximilians-Universität MünchenPRP. RaschkeKlinikum rechts der Isar

Discussion

Loading...

Member takes

Implication

May warrant caution against clinical extrapolation; leaves open A1 receptor modulation as a target in human postischemic injury.

Structured PICO

P
Population
Isolated perfused guinea pig hearts injected with 600,000 neutrophils prepared from guinea pig or human blood
I
Intervention
Adenosine infusion (0.1-1 microM), A1 receptor agonist N6-cyclopentyladenosine (CPA, 0.01 microM), or 15 min total ischemia
C
Comparator
Control (baseline adhesion without adenosine/agonist or ischemia)
O
Outcome
Adhesion of neutrophils to coronary endothelium (determined by the number of cells emerging in the coronary effluent)surrogate

Submicromolar adenosine levels enhance neutrophil adhesion via endothelial A1 receptors, suggesting a bimodal role of adenosine in postischemic dysfunction and cardioprotection.

Cite This Study

Zahler et al. (1994) studied this question.

synapsesocial.com/papers/6a82a13850b6b35c4f8adecfhttps://doi.org/10.1093/cvr/28.9.1366
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Release of adenosine and cyclic AMP from coronary endothelium in isolated guinea pig hearts: relation to coronary flow.1987 · 48 citations
  2. 2Adenosine Endogenously Released During Early Reperfusion Mitigates Postischemic Myocardial Dysfunction by Inhibiting Platelet Adhesion1998 · 34 citations
  3. 3Effects of adenosine receptor agonists on guinea-pig isolated working hearts and the role of endothelium and NO2002 · 21 citations
  4. 4Role of A1adenosine receptor in the regulation of coronary flow2006 · 41 citations
  5. 5Role of Adenosine in Catecholamine-Induced Global Coronary Functional Hyperemia in Isolated Guinea Pig Hearts1990 · 6 citations