Key result
Deletion of the A1 adenosine receptor significantly increased basal coronary flow in isolated mouse hearts compared to wild-type controls (2.548 vs 2.059 ml/min, P<0.05).
Why the study?
Does the A1 adenosine receptor regulate adenosine-induced changes in coronary flow in isolated mouse hearts?
Population
Isolated hearts from A1AR(-/-) and A1AR(+/+) mice
Comparison
Perfusion with adenosine receptor agonists and… vs A1AR hearts and baseline measurements
Design
Preclinical
Authors
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Hypothesis-generating for A1 receptor modulation of coronary tone; extends preclinical adenosine signaling data but leaves human translation open.
Does the A1 adenosine receptor regulate adenosine-induced changes in coronary flow in isolated mouse hearts?
Absolute Event Rate: 2.548% vs 2.059%
p-value: p=< 0.05
The A1 adenosine receptor negatively modulates coronary flow and inhibits vasodilation mediated by other adenosine receptor subtypes.
Tawfik et al. (2006) studied this question. A1 adenosine receptor deletion (A1AR-/-) vs. A1AR(+/+) wild-type was evaluated on Basal coronary flow (ml/min) (p=< 0.05). Deletion of the A1 adenosine receptor significantly increased basal coronary flow in isolated mouse hearts compared to wild-type controls (2.548 vs 2.059 ml/min, P<0.05).
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