Population
Isolated hearts from young (1-2 months) and mature (12-18 months) Wistar rats
Comparison
Adenosine receptor agonists and selective… vs Absence of antagonists, and comparison between…
Design
Preclinical
Authors
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Age-related coronary vasoreactivity decline warrants caution in elderly models; leaves open adenosine receptor roles in human aging.
In rat coronary circulation, vasodilation is mediated by multiple adenosine receptor subtypes (A2B and A3, but not A1 or A2A) and the magnitude of this response decreases with age.
Hinschen et al. (2003) studied this question.
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