What does this research mean for the field?

Global research on the pharmacological effects of earthworms is steadily increasing, with major focus areas including bioactive proteins, anti-inflammatory, antitumor, and cardiovascular applications, although evidence remains predominantly preclinical. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To systematically map global research trends, collaborative networks, and therapeutic hotspots concerning earthworms (Dilong) in pharmacology.

September 8, 2026Beni-Suef University Journal of Basic and Applied SciencesOpen Access

Bibliometric analysis on the pharmacological/therapeutic effects of earthworms (Dilong)

View Full Paper

Ask AI

Bookmark

Authors

XLXinyue Luo MDMengjie DU WHWei Huang

Discussion

Member takes

Overview

Bibliometric analysis reveals expanding preclinical research on earthworm therapeutics in cardiovascular and oncology domains, highlighting a need for robust clinical validation.

Key Points

To systematically map global research trends, collaborative networks, and therapeutic hotspots concerning earthworms (Dilong) in pharmacology.
Retrieved 313 publications indexed from 1989 to 2024 from the Web of Science Core Collection.
Analyzed author, institutional, and country collaboration networks alongside keyword co-occurrences using Bibliometrix and CiteSpace.
Publication volume increased steadily, with Asian institutions contributing over 60% of outputs and China representing the largest share at 34.2%, followed by the United States.
Thematic clustering revealed three major areas: bioactive protein characterization (chiefly lumbrokinase and antimicrobial peptides), anti-inflammatory and antitumor mechanisms, and thrombolytic applications.
Pharmacological validation remains concentrated in in vitro and animal models, with emerging research integrating cryo-electron microscopy and nanoparticle-based drug delivery.

Cite This Study

Luo et al. (2026) studied this question.

synapsesocial.com/papers/6aa0091858e84d0ff5b47bc4 https://doi.org/10.1186/s43088-026-00835-x

View Full Paper

Ask AI

Bookmark

September 8, 2026Beni-Suef University Journal of Basic and Applied SciencesOpen Access

Bibliometric analysis on the pharmacological/therapeutic effects of earthworms (Dilong)

View Full Paper

Ask AI

Bookmark

Authors

XLXinyue Luo MDMengjie DU WHWei Huang

Discussion

Member takes

Overview

Bibliometric analysis reveals expanding preclinical research on earthworm therapeutics in cardiovascular and oncology domains, highlighting a need for robust clinical validation.

Key Points

To systematically map global research trends, collaborative networks, and therapeutic hotspots concerning earthworms (Dilong) in pharmacology.
Retrieved 313 publications indexed from 1989 to 2024 from the Web of Science Core Collection.
Analyzed author, institutional, and country collaboration networks alongside keyword co-occurrences using Bibliometrix and CiteSpace.
Publication volume increased steadily, with Asian institutions contributing over 60% of outputs and China representing the largest share at 34.2%, followed by the United States.
Thematic clustering revealed three major areas: bioactive protein characterization (chiefly lumbrokinase and antimicrobial peptides), anti-inflammatory and antitumor mechanisms, and thrombolytic applications.
Pharmacological validation remains concentrated in in vitro and animal models, with emerging research integrating cryo-electron microscopy and nanoparticle-based drug delivery.

Cite This Study

Luo et al. (2026) studied this question.

synapsesocial.com/papers/6aa0091858e84d0ff5b47bc4 https://doi.org/10.1186/s43088-026-00835-x

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark