Key result
The incidence of all stroke decreased significantly by 1.5% per year in the diabetic population (RR 0.985) over a 17-year period, while remaining stable in the non-diabetic population.
Why the study?
Does the incidence of stroke decrease over time in the diabetic population compared to the non-diabetic population?
Observational (n=3,111)
No
Does the incidence of stroke decrease over time in the diabetic population compared to the non-diabetic population?
Relative Risk: 0.985 (95% CI 0.972–0.9995)
p-value: p=<0.05
Between 1998 and 2014, the incidence of stroke decreased significantly in the diabetic population in Germany, narrowing the risk gap compared to the non-diabetic population.
Stroke incidence fell in diabetes but held steady without; supports care improvements yet leaves open confirmation in prospective data.
One major objective of the St. Vincent Declaration was to reduce excess risk of stroke in people with diabetes mellitus. The aim of this study is to estimate the trend of incidence and relative risk of stroke in the diabetic and the non-diabetic populations in Germany over a 17-year period. We estimated age-sex standardised incidence rates of all stroke and ischaemic stroke in people with and without diabetes based on an ongoing prospective community-based stroke register covering 105,000 inhabitants. Time trends were analysed using Poisson regression. In total, 3,111 individuals (diabetes: 28.4%, men 46.9%, mean age 73.1 years (SD 13.2)) had a first stroke, 84.9% of which were ischaemic stroke. Among people with diabetes we observed a significant reduction in all stroke incidence by 1.5% per year (relative risk: 0.985; 95% confidence interval 0.972-0.9995) Likewise, this incidence tended to decrease for ischaemic stroke by 1% per year (0.993; 0.979-1.008). In contrast, the incidence rate for all stroke remained nearly stable among people without diabetes (1.003; 0.993-1.013) and for ischaemic stroke (1.002; 0.991-1.013). The relative risk comparing diabetic and non-diabetic population decreased for all stroke (two percent annual reduction) but not for ischaemic stroke. Time trends were similar for both sexes regarding all and ischaemic strokes. We found a reduction in risk of stroke in the diabetic population while this rate did not materially change in the non-diabetic population.
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Icks et al. (2017) conducted an observational in First-ever stroke (n=3,111). Diabetes mellitus vs. Non-diabetic population was evaluated on Annual trend in incidence of all stroke (RR 0.985, 95% CI 0.972-0.9995, p=<0.05). The incidence of all stroke decreased significantly by 1.5% per year in the diabetic population (RR 0.985) over a 17-year period, while remaining stable in the non-diabetic population.
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