Key result
Lercanidipine and amlodipine similarly reduced systolic and diastolic blood pressure over 12 weeks, but lercanidipine was associated with a considerably lower incidence of vasodilation-related side effects such as pedal edema.
Why the study?
Hypertension is a major global health concern in non-industrial nations, and this study aimed to compare the efficacy and tolerability of lercanidipine versus amlodipine in hypertensive patients.
Does lercanidipine reduce blood pressure and improve tolerability compared to amlodipine in patients with hypertension?
Cross-Sectional (n=120)
Non-probability consecutive sampling
No
Does lercanidipine reduce blood pressure and improve tolerability compared to amlodipine in patients with hypertension?
Absolute Event Rate: 133.4% vs 144%
Lercanidipine provides similar antihypertensive efficacy to amlodipine but with a better tolerability profile, particularly regarding the incidence of pedal edema.
Lercanidipine may offer better tolerability than amlodipine at similar efficacy; leaves open confirmation in randomized trials.
Introduction: Hypertension has been perceived as a worldwide health worry for non-industrial nations and is hardly depicted in a considerable lot of these nations. Objectives: The main objective of the study is to find the Comparison between lercanidipine and amlodipine for efficacy and tolerability in patients with hypertension. Material and methods: This cross sectional, comparative study was conducted in PIMS during January 2021 to June 2021. After permission from hospital ethical committee, total 120 patients meeting the inclusion and exclusion criteria will be enrolled in the study from Medical Emergency and admitted in PIMS. Detailed history, physical examination and necessary investigations will be done to meet the inclusion and exclusion criteria. Informed consent will be obtained. Results: The data was collected from 120 patients of both male and female. Table 01 shows the mean values of systolic and diastolic BP according to age and gender. The mean systolic and diastolic BP of all the study subjects were 124.2 ± 15.0 mmHg and 83.4 ± 9.5 mmHg, respectively. In men, the highest mean systolic BP and mean diastolic BP were among the eldest age group and preceding eldest age group. Conclusion: It is concluded that lercanidipine is associated with considerably lower incidence of vasodilation related side effects than amlodipine, especially pedal edema.
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Abrar et al. (2021) conducted a cross-sectional in Hypertension (n=120). Lercanidipine vs. Amlodipine (dose adjusted 2.5 mg, 5mg, 7.5 mg, 10 mg daily) was evaluated on Reduction in baseline systolic and diastolic blood pressure. Lercanidipine and amlodipine similarly reduced systolic and diastolic blood pressure over 12 weeks, but lercanidipine was associated with a considerably lower incidence of vasodilation-related side effects such as pedal edema.
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