Key result
Amisulpride overdose prolongs the QTc interval, and intravenous calcium is proposed to effectively restore the QT interval to normal.
Why the study?
Does intravenous calcium restore the QT interval to normal in a patient with amisulpride overdose?
Does intravenous calcium restore the QT interval to normal in a patient with amisulpride overdose?
Intravenous calcium may be an effective treatment for restoring normal QTc intervals in patients with amisulpride overdose.
May warrant consideration in amisulpride overdose; hypothesis-generating and requires prospective confirmation before practice change.
A case of amisulpride overdose is presented and its effect on prolonging the QT (corrected) interval is discussed. Amisulpride is used for the treatment of schizophrenia and part of its safety profile is that is has no effect on the QT interval in therapeutic doses. The efficacy of intravenous calcium in restoring the QT to normal is proposed.
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Richard J. Stevenson (2010) studied this question. Amisulpride overdose prolongs the QTc interval, and intravenous calcium is proposed to effectively restore the QT interval to normal.
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