Key result
Amisulpride overdose caused severe cardiac toxicity in four patients, including QT prolongation >500 ms in all four, torsades de pointes in two, and one death from cardiac arrest.
Why the study?
Does amisulpride overdose cause severe cardiac toxicity?
Case Report (n=4)
Yes
Does amisulpride overdose cause severe cardiac toxicity?
Amisulpride overdose can cause severe cardiac toxicity including QT prolongation and torsades de pointes, necessitating prolonged ECG monitoring.
Amisulpride overdose may cause severe cardiotoxicity; leaves open optimal monitoring protocols pending prospective studies.
Although clinical trials of the antipsychotic amisulpride revealed no cardiac adverse effects, four patients with severe cardiac toxicity after overdose were reported to Australian poisons information centres in 2004-2005. All four had QT prolongation over 500 ms, two had rate-dependent bundle branch block, two developed torsades de pointes, and one died after cardiac arrest. Pending further studies, we recommend electrocardiogram assessment until at least 16 h after amisulpride overdose and, if QT interval is prolonged, cardiac monitoring until the patient is clinically well and conduction intervals are normal.
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Isbister et al. (2006) conducted a case report in Amisulpride overdose (n=4). Amisulpride overdose was evaluated on Severe cardiac toxicity. Amisulpride overdose caused severe cardiac toxicity in four patients, including QT prolongation >500 ms in all four, torsades de pointes in two, and one death from cardiac arrest.