Key result
Macroscopic cardiac remodeling occurs during the latent stage of neuroleptic cardiomyopathy and ceases at the full-scale stage, after which progression is driven by microstructural changes.
Why the study?
Heart condition on the organ level of organization had not been comparatively evaluated across clinical stages of neuroleptic cardiomyopathy using morphometric methods.
Observational (n=180)
Macroscopic cardiac remodeling in neuroleptic cardiomyopathy occurs primarily during the latent stage, with further progression to heart failure driven by microstructural changes rather than further organ-level remodeling.
Morphometric remodeling data in neuroleptic cardiomyopathy remain hypothesis-generating; prospective studies needed before clinical adoption.
Aim: A comparative morphometric study of heart condition on the organ level of its organization in each clinical stage of neuroleptic cardiomyopathy. Methods and Results: In compliance with the modern requirements of evidential medicine the morphometric method of a research differing in objectivity and high informational content is used. For analysis of data from organometry of heart an own original method was used. It was found that on the organ level the process of cardiac remodeling ends during the latent stage of the disease. Progression of myocardial dysfunction is connected with the changes. Conclusion: During the morphogenesis of an antipsychotic cardiomyopathy a certain definition of the stage of clinical manifestations of a disease corresponding to the remodeling of the heart at the organ level is observed.
No takes yet. Share an insight, caveat, or question.
Volkov VP (2019) conducted an observational in Neuroleptic cardiomyopathy (n=180). Neuroleptic cardiomyopathy vs. Persons without cardiac pathology was evaluated on Macroscopic morphometric parameters of the heart (mass, volume, mass-volume ratio, index of density of myocardium) (p=≤0.05). Macroscopic cardiac remodeling occurs during the latent stage of neuroleptic cardiomyopathy and ceases at the full-scale stage, after which progression is driven by microstructural changes.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: