Morphometric Approach to the Study of Morphogenesis of a Neuroleptic Cardiomyopathy

Aim: In is a comparative morphometric study of myocardium in each clinical stage of neuroleptic cardiomyopathy. Methods: Myocardium was histomorphometrically examined in 58 cases of neuroleptic cardiomyopathy and in 22 control persons without cardiac pathology. Result: The studied micromorphometric parameters describe the condition of three structural components of myocardium (vasculature, intercellular matrix, and parenchyma). In the latent stage the microcirculatory disorders prevail. In the full-scale stage the damages of intercellular matrix come to the forefront. For the terminal stage the atrophic and dystrophic-degenerative changes of cardiomyocytes are characteristic. Conclusion: In the course of morphogenesis of a neuroleptic cardiomyopathy a certain staging of clinical manifestations of the disease is observed; this staging corresponds to an observed chain of interconnected pathologic shifts in all microstructures of myocardium.