Straightforward and Stereoselective Synthesis of α,β‐Diamino Acid Derivatives by Means of an Organocatalyzed Decarboxylative Mannich Reaction

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A rapid and convenient method has been developed for the stereoselective synthesis of α,β‐diamino acid derivatives from amido‐substituted malonic acid half oxyesters (MAHOs) and imines. The anti products were obtained with a diastereomeric ratio up to 99:1 by using a decarboxylative Mannich reaction catalyzed by commercially available 1,4‐diazabicyclo[2.2.2] octane (DABCO).