Key result
Bilateral lesions of the medial vestibular nucleus significantly attenuated the hyperventilation and hypertension responses to fastigial nuclear stimulation and hypercapnia, but not to hypoxia.
Population
21 anesthetized, tracheotomized, and spontaneously breathing rats
Comparison
Bilateral lesions of the medial vestibular… vs Baseline responses before VNM lesions
Design
Preclinical, Animals were exposed to hypercapnia and hypoxia randomly before…
Authors
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Medial vestibular nucleus findings in rats warrant no clinical change; leaves open its role in human hypercapnic responses pending translational studies.
The medial vestibular nucleus is required for the full expression of cardiorespiratory responses to fastigial nuclear stimulation and hypercapnia in rats.
Hernandez et al. (2004) studied Cardiorespiratory responses (n=21). Bilateral lesions of the VNM by local microinjection of ibotenic acid vs. Before VNM lesions was evaluated on Cardiorespiratory responses (hyperventilation and hypertension) to FN stimulation, hypercapnia, and hypoxia. Bilateral lesions of the medial vestibular nucleus significantly attenuated the hyperventilation and hypertension responses to fastigial nuclear stimulation and hypercapnia, but not to hypoxia.
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