Key result
Optical imaging of the pre-Bötzinger complex in juvenile rats revealed a spatial mixture of phase-spanning and postinspiratory-related activity, along with widespread hyperpolarization during expiration.
Population
Arterially perfused in situ preparation of the juvenile rat
Design
Preclinical
Authors
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No immediate clinical implications for respiratory disorders; leaves open the role of inhibitory networks in human rhythmogenesis.
High-speed voltage-sensitive dye imaging reveals widespread hyperpolarization during expiration in the pre-Bötzinger complex of juvenile rats, supporting the role of inhibitory neurons in respiratory phase transition.
Fisher et al. (2005) studied Respiratory rhythmogenesis. High-speed voltage-sensitive dye imaging was evaluated on Spatial distribution of respiratory neuronal activity in the ventrolateral respiratory group. Optical imaging of the pre-Bötzinger complex in juvenile rats revealed a spatial mixture of phase-spanning and postinspiratory-related activity, along with widespread hyperpolarization during expiration.
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