Key result
Mammalian carotid bodies utilize synaptic and paracrine mechanisms involving ATP, adenosine, serotonin, GABA, and dopamine to mediate respiratory and cardiovascular reflexes during hypoxia.
This review highlights the complex synaptic and paracrine signaling mechanisms that mediate the response of mammalian carotid bodies to hypoxia and hypercapnia.
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Carotid body P2X2/3 signaling may guide reflex-targeted therapies in HF or hypertension; leaves open clinical translation from basic models.
Colin A. Nurse (2014) reported a review. Mammalian carotid bodies utilize synaptic and paracrine mechanisms involving ATP, adenosine, serotonin, GABA, and dopamine to mediate respiratory and cardiovascular reflexes during hypoxia.
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