Key result
Carrying the G allele of TGFBR2 SNP rs6785358 was associated with a higher risk of congenital heart defects compared with AA homozygotes (OR 1.545; 95% CI 1.013-2.356), particularly in men.
Why the study?
Are TGFBR2 gene polymorphisms associated with an increased risk of congenital heart defects in a Han Chinese population?
Case-Control (n=740)
Are TGFBR2 gene polymorphisms associated with an increased risk of congenital heart defects in a Han Chinese population?
Odds Ratio: 1.545 (95% CI 1.013–2.356)
p-value: p=0.043
The TGFBR2 gene polymorphism rs6785358 is associated with an increased risk of congenital heart defects in Han Chinese men.
No takes yet. Share an insight, caveat, or question.
No immediate clinical implications for CHD management; leaves open causal role of TGFBR2 variants pending replication.
Huang et al. (2014) conducted a case-control in Congenital heart defects (n=740). TGFBR2 gene polymorphism rs6785358 G allele (AG/GG genotype) vs. AA homozygotes was evaluated on Congenital heart defects (OR 1.545, 95% CI 1.013-2.356, p=0.043). Carrying the G allele of TGFBR2 SNP rs6785358 was associated with a higher risk of congenital heart defects compared with AA homozygotes (OR 1.545; 95% CI 1.013-2.356), particularly in men.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: