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several other promising candidate genes, including neuregulin-1 and dysbindin. 12Interestingly, neuregulin-1 and dysbindin proteins are known to have important roles in neurodevelopment and synaptic functions, like DISC-1.In addition to deficits in neural development, several aspects of the pathogenesis of schizophrenia have been studied, including dysfunctions of glutamatergic and dopaminergic neurotransmission.Possible environmental factors superimposed on genetic vulnerability include virus infection as well as gestational and birth complications.By studying genetically engineered mice with susceptibility factors such as DISC-1 in combination with environmental stresses, it may be possible to provide a more definitive, integrated model for the pathogenesis of schizophrenia in the future.